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Azonox 200 Tablet 1 Strip
Itraconazole – Broad-Spectrum Antifungal Therapy | Now enhanced with SUBA (Super Bio-Available) Technology
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✅ Description:
Azonox is indicated for the treatment and prevention of a wide range of fungal infections, including:
Superficial and mucocutaneous infections:
- Oropharyngeal candidiasis
- Vulvovaginal candidiasis
- Pityriasis versicolor
- Tinea pedis, tinea cruris, tinea corporis, tinea manuum
Onychomycosis (nail infections)
Systemic fungal infections:
- Systemic candidiasis
- Aspergillosis
- Cryptococcosis (including cryptococcal meningitis)
- Histoplasmosis
Prophylaxis & Maintenance:
- Maintenance therapy in HIV/AIDS patients to prevent relapse of fungal infections
- Prophylaxis during prolonged neutropenia
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pharmacology
Itraconazole works by inhibiting fungal cytochrome P450 enzymes, blocking the synthesis of ergosterol, a critical component of fungal cell membranes. This disrupts membrane integrity, inhibiting growth and causing fungal cell death.
💡 SUBA Technology: Azonox utilizes SUBA (Super Bio-Available) delivery to significantly improve absorption and efficacy of itraconazole, ensuring reliable plasma concentrations for optimal antifungal activity.
✔️ Side Effects
Nausea, indigestion, abdominal pain, headache, dizziness, constipation
Occasional:
Elevated liver enzymes, menstrual irregularities, and allergic skin reactions
Rare:
Hepatitis, cholestatic jaundice, Stevens-Johnson syndrome, peripheral neuropathy, hypokalemia, hair loss, edema
✔️ Dosage & Administration | 100 mg / 200 mg Formulations:
Superficial Infections
Vulvovaginal candidiasis: 200 mg twice daily for 1 day
Pityriasis versicolor: 200 mg once daily for 7 days
Tinea corporis/cruris: 100 mg daily for 15 days or 200 mg daily for 7 days
Tinea pedis/manuum: 100 mg daily for 30 days
Oropharyngeal candidiasis: 100 mg daily for 15 days (200 mg for AIDS/neutropenia)
Onychomycosis:
Continuous: 200 mg daily for 3 months
Pulse: 200 mg twice daily for 7 days; repeat after 21 days (2–3 courses)
Systemic Infections
Aspergillosis: 200 mg daily for 2–5 months (increase to twice daily for invasive disease)
Candidiasis: 100–200 mg daily for 3 weeks–7 months
Cryptococcosis (non-CNS): 200 mg daily for 10 weeks
Cryptococcal meningitis: 200 mg twice daily for 2–6 months
Histoplasmosis: 200 mg once/twice daily for up to 8 months
AIDS maintenance or neutropenia prophylaxis: 200 mg daily
✔️ Pediatric Use
Safety and efficacy in children have not been established.
✔️ Contraindications
Known hypersensitivity to itraconazole
Severe hepatic impairment
Concurrent use with rifampin, terfenadine, astemizole, cisapride, simvastatin, oral midazolam, triazolam, and similar agents
✔️ Pregnancy & Lactation
Contraindicated during pregnancy
Not recommended during breastfeeding
✔️ Drug Interactions
Significant interactions with:
Rifampin, phenytoin, phenobarbital
Digoxin, calcium channel blockers
Simvastatin, midazolam, terfenadine, cisapride
Avoid or closely monitor these combinations
✔️ Precautions & Warnings
Take with a full meal to enhance absorption
Avoid co-administration with antacids or H2 blockers; if necessary, separate by at least 2 hours
Monitor liver function during prolonged therapy (≥1 month)
Caution in cardiac or hepatic dysfunction
✔️ Storage
Store at below 25°C in a cool, dry place
Keep away from light and out of children's reach
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
